Desogestrel

• Description :

  Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3][4].

• CAS Number :

  [54024-22-5]

• Product Name Alternative :

  Org-2969

• UNSPSC :

  12352211

• Hazard Statement :

  H410

• Target :

  Progesterone Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Desogestrel.html

• Purity :

  99.42

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles :

  [H][C@@]12C(CC[C@]([C@@](CC[C@@]3(O)C#C)([H])[C@]3(CC)C4)([H])[C@]2([H])C4=C)=CCCC1

• Molecular Formula :

  C22H30O

• Molecular Weight :

  310.47

• Precautions :

  H410

• References & Citations :

  [1]Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287 (2) :289-94.|[2]Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception. 1996 Feb;53 (2) :85-90.|[3]Barkfeldt J, et al. The effects of two progestogen-only pills containing either desogestrel (75 microg/day) or levonorgestrel (30 microg/day) on lipid metabolism. Contraception. 2001 Nov;64 (5) :295-9.|[4]Grandi G, et al. Pharmacokinetic evaluation of desogestrel as a female contraceptive. Expert Opin Drug Metab Toxicol. 2014 Jan;10 (1) :1-10.|[5]Cardani S, et al., Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 Sep 15;370 (2) :671-679.|[6]Xie H, et al., Effect of progestin on thyroid function in female Wistar rats. Front Endocrinol (Lausanne) . 2024 Jun 5;15:1362774.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched