Desogestrel

CAT: 0804-HY-12516-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12516-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3][4].
CAS Number
[54024-22-5]
Product Name Alternative
Org-2969
UNSPSC
12352211
Hazard Statement
H410
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Desogestrel.html
Purity
99.42
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
[H][C@@]12C(CC[C@]([C@@](CC[C@@]3(O)C#C)([H])[C@]3(CC)C4)([H])[C@]2([H])C4=C)=CCCC1
Molecular Formula
C22H30O
Molecular Weight
310.47
Precautions
H410
References & Citations
[1]Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287 (2) :289-94.|[2]Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception. 1996 Feb;53 (2) :85-90.|[3]Barkfeldt J, et al. The effects of two progestogen-only pills containing either desogestrel (75 microg/day) or levonorgestrel (30 microg/day) on lipid metabolism. Contraception. 2001 Nov;64 (5) :295-9.|[4]Grandi G, et al. Pharmacokinetic evaluation of desogestrel as a female contraceptive. Expert Opin Drug Metab Toxicol. 2014 Jan;10 (1) :1-10.|[5]Cardani S, et al., Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 Sep 15;370 (2) :671-679.|[6]Xie H, et al., Effect of progestin on thyroid function in female Wistar rats. Front Endocrinol (Lausanne) . 2024 Jun 5;15:1362774.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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