HPV16 E2 Antibody

CAT: 0800-V8839SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V8839SAF-100UGSize:100 µg
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Description
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
Not Applicable
Host
Mouse
Reactivity
HPV-16
Immunogen
Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
Clonality
Monoclonal
Isotype
IgG1 k
Clone
TVG 261
Applications
WB
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the HPV16 E2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HPV16 E2 antibody is available for research use only.
Storage Conditions
Aliquot the HPV16 E2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the HPV16 E2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
SDS-PAGE analysis of purified, BSA-free HPV16 E2 antibody (TVG 261) as confirmation of integrity and purity.

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