Plasma kallikrein-IN-5

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804-HY-163464

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UNSPSC Description: Plasma kallikrein-IN-5 (Compound 20) is a potent covalent inhibitor of plasma potassium kinin peptide (Pka) with IC50 values of 66 nM and 70 pM at 1 minute and 24 hours, respectively. Plasma kallikrein-IN-5 can be used IN the study of hereditary angioedema (HAE)[1].
Target Antigen: Kallikrein
Type: Reference compound
Related Pathways: Immunology/Inflammation
Applications: Neuroscience-Neuromodulation
Field of Research: Cardiovascular Disease
Assay Protocol: https://www.medchemexpress.com/plasma-kallikrein-in-5.html
Solubility: 10 mM in DMSO
Smiles: CC1=CC(F)=C(C=C1)C(B2OC(C)(C(C)(O2)C)C)NC(C3=CN(N=C3)CC4=CC=C(C=C4)CN5C=CC=N5)=O
Molecular Weight: 529.41
References & Citations: [1]Allison M, et al. Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein. ACS Med Chem Lett. 2024 Mar 28;15(4):501-509.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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HY-163464	Plasma kallikrein-IN-5
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