Plasma kallikrein-IN-2

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804-HY-143476

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UNSPSC Description: Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC50 of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research[1].
Target Antigen: Kallikrein
Type: Reference compound
Related Pathways: Immunology/Inflammation
Applications: Metabolism-protein/nucleotide metabolism
Field of Research: Metabolic Disease; Cardiovascular Disease
Assay Protocol: https://www.medchemexpress.com/plasma-kallikrein-in-2.html
Solubility: 10 mM in DMSO
Smiles: O=C1[C@H]2[C@H](C2)CN1C3=NC=C(C(N4C=C(C=N4)NC(C5=NC(C6=C(C=CC(Cl)=C6F)C(F)F)=CN=C5CO)=O)C)N=C3C
Molecular Weight: 612.99
References & Citations: [1]Ram W. Sabnis, et al. Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy. ACS Med Chem Lett. 2022 Mar 4;13(4):528-529.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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