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OPBP-1

CAT: 0804-HY-P10424-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10424-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research[1].
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/opbp-1.html
Purity
99.88
Solubility
H2O : 5 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H](CCC(O)=O)C(N[C@H](CC1=CNC=N1)C(N[C@H](CC2=CNC=N2)C(N[C@H](CCSC)C(N[C@H](CCCNC(N)=N)C(N[C@H](C(C)C)C(N[C@H](CC3=CC=C(C=C3)O)C(N[C@H](CO)C(N[C@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C64H92N20O19S
Molecular Weight
1477.60
References & Citations
[1]Li W, et al. An orally available PD-1/PD-L1 blocking peptide OPBP-1-loaded trimethyl chitosan hydrogel for cancer immunotherapy[J]. Journal of Controlled Release, 2021, 334: 376-388.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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