OPB-3206

CAT: 0804-HY-171776Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171776Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7x10-7 M, 5x10-6 M, 5x10-7 M and 2x10-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma[1].
CAS Number
[166245-54-1]
UNSPSC
12352005
Target
MMP
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CON1C2=CC=CC=C2C[C@@H](C1=O)NC([C@H](CC(C)C)CC(NO)=O)=O
Molecular Formula
C18H25N3O5
Molecular Weight
363.41
References & Citations
[1]Kido A, et al. Inhibition of Spontaneous Rat Osteosarcoma Lung Metastasis by 3S‐[4‐ (Nhydroxyamino) ‐2R‐isobutylsuccinyl] amino‐1‐methoxy‐3, 4‐dihydrocarbostyril, a Novel Matrix Metalloproteinase Inhibitor[J]. Japanese journal of cancer research, 1999, 90 (3) : 333-341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9

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