LNX1

• Background:

  LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65

• Synonyms:

  Numb-Binding Protein 1, Ligand of Numb-Protein X 1

• UniProt:

  Q8TBB1

• Host:

  Rabbit

• Species Reactivity:

  Human

• Conjugation:

  Unconjugated

• Type:

  Blocking Peptide

• Applications:

  WB

• Assay Principle:

  For use with LNX1 polyclonal antibodies (Cat. No. X2316P , X2340P).

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Armbruester, V., et al. 'Np9 protein of Human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004). 2. Sollerbrant, K., et al. 'The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003). 3. Xie, Y., et al. 'Identification of a Human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB