LNX2

• Background :

  Interacts with the phosphotyrosine interaction domain of Numb. Lnx proteins may server as molecular scaffolds that localize unrelated, interacting proteins, such as Numb, to specific subcellular sites. Forms oligomers via their PDZ binding domains to PDZ-binding consensus motifs located in their C-termini or by homophilic oligomerization of their RING fingers.

• Synonyms :

  Numb-Binding Protein 2, PDZ Domain-containing RING finger Protein 1

• UniProt :

  Q8N448

• Host :

  Rabbit

• Species Reactivity :

  Human

• Conjugation :

  Unconjugated

• Type :

  Blocking Peptide

• Applications :

  WB

• Assay Principle :

  For use with LNX2 polyclonal antibodies (Cat. No. X2317P , X2345P).

• Stability :

  See expiration date on vial

• Concentration :

  See vial for Concentration

• Form :

  Provided as solution in phosphate buffered saline

• Precautions :

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations :

  1. Rice, D.S., et al. 'The Lnx family proteins function as molecular scaffolds for Numb family proteins.' Mol Cell Neurosci. 2001 Nov;18(5):525-40. 2. Mirza, M., et al. 'The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).' Exp Cell Res. 2005 Sep 10;309(1):110-20.

• Shipping Conditions :

  Ambient Temperature, freeze upon arrival

• Storage Conditions :

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis :

  WB