VE Cadherin Recombinant Rabbit Monoclonal Antibody [PSH03-15]

VE Cadherin Recombinant Rabbit Monoclonal Antibody [PSH03-15]

• Description: Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development . The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton. While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking . Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers . Research studies indicate that cancer cells have upregulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis. Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers .
• Product Name Alternative: 7B 4 antibody 7B4 antibody 7B4 antigen antibody CADH5_HUMAN antibody Cadherin 5 antibody Cadherin 5 type 2 antibody Cadherin 5, type 2 (vascular endothelium) antibody Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody cadherin, vascular endothelial antibody cadherin, vascular endothelial, 1 antibody Cadherin-5 antibody Cadherin5 antibody CD 144 antibody CD144 antibody CD144 antigen antibody CDH 5 antibody CDH5 antibody CDH5 protein antibody Endothelial specific cadherin antibody FLJ17376 antibody OTTHUMP00000174777 antibody Vascular endothelial cadherin antibody Vascular epithelium cadherin antibody VE Cad antibody VE-cadherin antibody VEC antibody
• Abbreviation: 7B4 antigen Vascular endothelial cadherin (VE-cadherin)
• CAS Number: 9000-83-3
• Swiss Prot: P33151 Human
• Cellular Locus: Cell junction. Cell membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within human VECadherin aa 1-650 / 784.
• Isotype: IgG
• Clone: PSH03-15
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: EA.hy926 cell lysates, human lung tissue lysate, human kidney tissue lysate, EA.hy926.
• Concentration: 1 mg/mL
• Dilution: WB:1:2,000 ;IF-Cell:1:100 ;FC:1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 88 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes