H Cadherin Recombinant Rabbit Monoclonal Antibody [JB14-48]

H Cadherin Recombinant Rabbit Monoclonal Antibody [JB14-48]

• Description: Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.
• Product Name Alternative: CAD13_HUMAN antibody Cadherin-13 antibody CDH13 antibody CDHH antibody H-cadherin antibody Heart cadherin antibody P105 antibody T cad antibody T Cadherin antibody T-cad antibody T-cadherin antibody Truncated cadherin antibody
• Abbreviation: H-cadherin, T-cad, T-cadherin, CDH13, CDHH
• CAS Number: 9000-83-3
• Swiss Prot: P55290 Human, Q9WTR5 Mouse, Q8R490 Rat
• Cellular Locus: Cell membrane, Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human H Cadherin aa 81-220 / 713.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IHC-P, WB
• Positive Control: Human colon carcinoma tissue, human kidney tissue, rat skeletal muscle tissue, mouse heart tissue.
• Concentration: 1 mg/mL
• Dilution: IHC-P: 1:50-1:1,000 ;WB: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 78 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes