Cadherin 10 Rabbit Polyclonal Antibody

Cadherin 10 Rabbit Polyclonal Antibody

• Description: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.
• Product Name Alternative: CAD10_HUMAN antibody Cadherin 10 (T2 cadherin) antibody Cadherin 10 type 2 (T2 cadherin) antibody Cadherin 10 type 2 antibody Cadherin-10 antibody Cadherin10 antibody CDH10 antibody T2 cadherin antibody T2-cadherin antibody
• Abbreviation: CDH10
• CAS Number: 9007-83-4
• Swiss Prot: Q9Y6N8 Human, P70408 Mouse
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within C-terminal human Cadherin 10.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB
• Positive Control: SH-SY5Y cell lysates, mouse hippocampus tissue lysates.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 88 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No