L5-DA

• Description:

  L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM) . L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; G-quadruplex

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/l5-da.html

• Purity:

  99.03

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CN(CCOC1=CC2=C(N(C=C2)C3=CC=C4C=CC(N5C=CC6=C5C=CC(OCCN(C)C)=C6)=NC4=N3)C=C1)C

• Molecular Formula:

  C32H34N6O2

• Molecular Weight:

  534.65

• References & Citations:

  [1]Wang Y, et al. A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology. Bioorg Med Chem. 2021;48:116416.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2986876-41-7]