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TD114-2

CAT: 0804-HY-136679Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136679Size:1 Each
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Description
TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50=48 nM) . TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3β, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β[1].
CAS Number
436866-52-3
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/td114-2.html
Smiles
O=C(N1)C(C2=CN(CCOCCOCCOCCOCC3)C4=CC=CC=C24)=C(C1=O)C5=CN3C6=CC=CC=C56
Molecular Formula
C30H31N3O6
Molecular Weight
529.58
References & Citations
[1]Kuo G H, et al. Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3β inhibitors[J]. Journal of medicinal chemistry, 2003, 46 (19) : 4021-4031.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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