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TD114-2

CAT: 0931-T88327-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88327-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
436866-52-3
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells
Bioactivity
TD114-2 (compound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 of 48 nM. It forms a hydrogen bond with Arginine 141 (ARG141) in GSK-3β, an amino acid often found as a negatively charged residue in other kinases, contributing to its high selectivity. TD114-2 is applicable for research on diabetes, neurodegenerative diseases, and other conditions related to GSK-3β.
Smiles
O=C1NC(=O)C=2C3=CN(C=4C=CC=CC34)CCOCCOCCOCCOCCN5C=C(C=6C=CC=CC65)C12
Molecular Formula
C30H31N3O6
Molecular Weight
529.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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