BAY-179

• Description :

  BAY-179, a chemical probe, is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively[1].

• UNSPSC :

  12352005

• Target :

  Mitochondrial Metabolism

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bay-179.html

• Purity :

  99.83

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C12=C(OC(C3=CSC(C4CCN(CC5=NC6=C(C=CC=N6)N5)CC4)=N3)=C2)C=CC=C1

• Molecular Formula :

  C23H21N5OS

• Molecular Weight :

  415.51

• References & Citations :

  [1]Mowat J, et al. Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179. ACS Med Chem Lett. 2022;13 (3) :348-357. Published 2022 Feb 18.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2764880-87-5]