PKI-179

CAT: 0804-HY-11080-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-11080-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo[1][2].

CAS Number

1197160-28-3

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pki-179.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=NC=C1)NC2=CC=C(C3=NC(N4C5CCC4COC5)=NC(N6CCOCC6)=N3)C=C2

Molecular Formula

C25H28N8O3

Molecular Weight

488.54

References & Citations

[1]Venkatesan AM, et, al. PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K) /mammalian target of rapamycin (mTOR) inhibitor. Bioorg Med Chem Lett. 2010 Oct 1;20 (19) :5869-73.|[2]Rehan M. A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches. J Mol Graph Model. 2015 Nov;62:226-234.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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Alternative Products

Catalog	Name
T36084-01	PKI-179
T36085-01	PKI-179 hydrochloride
471200	PKI-179 HCl
GTR19203251-01	PKI-166
A8505-5	PKI-402
5-01772	PKI-tide
329788-01	Pki alpha
345376-01	PKI β discontinued

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