CT-179

• Description :

  CT-179 is an OLIG2 inhibitor with brain permeability and oral availability. CT-179 inhibits its transcriptional activity by disrupting OLIG2 dimerization, phosphorylation, and DNA binding. CT-179 induces G2/M phase arrest, promotes apoptosis, and differentiation in tumor cells. CT-179 can be used for cancer research[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; OLIG2

• Related Pathways :

  Apoptosis; Neuronal Signaling

• Field of Research :

  Cancer

• Smiles :

  CC1=NC(NC(NC2=CC(Cl)=C(C=C2)Cl)=O)=NC(NCCCN(C)C)=C1

• Molecular Formula :

  C17H22Cl2N6O

• Molecular Weight :

  397.30

• References & Citations :

  [1]Li Y, et al. Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nat Commun. 2025 Feb 4;16 (1) :1091.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1996636-69-1]