Nrf2-ARE/hMAO-B/QR2 modulator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1

• UNSPSC Description: Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC50s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices[1]. Nrf2-ARE/hMAO-B/QR2 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Keap1-Nrf2; Monoamine Oxidase; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nrf2-are-hmao-b-qr2-modulator-1.html
• Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1OC(/C=C/C2=CC=C(OC)C=C2)=NN1CC#C
• Molecular Weight: 256.26
• References & Citations: [1]Herrera-Arozamena C, Estrada-Valencia M, López-Caballero P, et al. Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. J Med Chem. 2022;65(6):4727-4751.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported