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Proteasome-activating peptide 1

CAT: 0804-HY-P3414Size: 1 EachDry Ice: NoHazardous: No
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Description
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis[1].
CAS Number
1565763-62-3
UNSPSC
12352209
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/proteasome-activating-peptide-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C([C@@H](N)[C@@H](C)CC)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CS)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C63H116N22O13S4
Molecular Weight
1517.99
References & Citations
[1]Dal Vechio FH, et al. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014;67:304-313.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Ile-Pro-Arg-Cys-Arg-Lys-Met-Pro-Gly-Val-Lys-Met-Cys-NH2
CAS Number1565763-62-3
PubChem CID168446598
IUPAC Name(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]-N-[2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]pyrrolidine-2-carboxamide
Molecular FormulaC63H116N22O13S4
Molecular Weight1518.0
XLogP-3.7
Topological Polar Surface Area634
Hydrogen Bond Donor Count20
Hydrogen Bond Acceptor Count22
Rotatable Bond Count50
Heavy Atom Count102
Formal Charge0
Complexity2810
SMILES
CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N)N
InChI
InChI=1S/C63H116N22O13S4/c1-7-36(4)48(66)61(98)85-29-15-21-46(85)58(95)78-40(19-13-27-73-63(70)71)54(91)82-44(34-100)56(93)76-39(18-12-26-72-62(68)69)52(89)75-37(16-8-10-24-64)53(90)80-42(23-31-102-6)60(97)84-28-14-20-45(84)57(94)74-32-47(86)83-49(35(2)3)59(96)79-38(17-9-11-25-65)51(88)77-41(22-30-101-5)55(92)81-43(33-99)50(67)87/h35-46,48-49,99-100H,7-34,64-66H2,1-6H3,(H2,67,87)(H,74,94)(H,75,89)(H,76,93)(H,77,88)(H,78,95)(H,79,96)(H,80,90)(H,81,92)(H,82,91)(H,83,86)(H4,68,69,72)(H4,70,71,73)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,48-,49-/m0/s1
InChIKey
SPNPUVHGIZATSM-HLMOKWPKSA-N
Chemical Structure
2D Structure
2D structure of H-Ile-Pro-Arg-Cys-Arg-Lys-Met-Pro-Gly-Val-Lys-Met-Cys-NH2
CAS: 1565763-62-3
CID: 168446598
Formula: C63H116N22O13S4
MW: 1518.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1518.0
XLogP3-3.7
Hydrogen Bond Donor Count20
Hydrogen Bond Acceptor Count22
Rotatable Bond Count50
Exact Mass1516.79750654
Monoisotopic Mass1516.79750654
Topological Polar Surface Area634 Ų
Heavy Atom Count102
Formal Charge0
Complexity2810
Isotope Atom Count0
Defined Atom Stereocenter Count13
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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