Products for Research Use Only
RegisterLogin

20S Proteasome activator 1

CAT: 0804-HY-150602-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-150602-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1].
CAS Number
2761578-18-9
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/20s-proteasome-activator-1.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)CCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35
Molecular Formula
C27H19ClF2N2OS
Molecular Weight
492.97
References & Citations
[1]Staerz SD, et al. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. J Med Chem. 2022 May 12;65 (9) :6631-6642.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-139331-0120S Proteasome-IN-1
HY-15815020S Proteasome-IN-5
HY-15059120S Proteasome-IN-3
HY-15059020S Proteasome-IN-2
HY-15119520S Proteasome-IN-4
HY-169134PROTAC 20S proteasome subunit β5 degrader 1
HY-P80876-01Proteasome 20S LMP7 Antibody (YA684, Mouse)
HY-P82002-01Proteasome 20S LMP2 Antibody (YA1747, Rabbit)
HY-P80437-01Proteasome 20S LMP7 Antibody (YA121, Rabbit)
HY-P85261Proteasome 20S LMP7 Antibody (YA4953, Rabbit)

Alternative Products

CatalogName
330764PSME4 (Proteasome activator complex subunit 4, Proteasome activator PA200, KIAA0077)
BUP06083-0120S Proteasome activator 1
350490-01PSME4, NT (Proteasome activator complex subunit 4, Proteasome activator PA200, KIAA0077)
abx262930-01Proteasome Activator Subunit 2 Protein
330784-01Proteasome activator complex subunit 3
DF13732-BPProteasome Activator Subunit 4 Peptide
DF13732-01Proteasome Activator Subunit 4 Antibody
AS19 4269Anti-PA200 | Proteasome activator PA200
abx262934-01Proteasome Activator Subunit 3 Protein
489646PSME2 (Proteasome Activator Complex Subunit 2, Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 beta)

Popular Products