Proteasome-IN-7

• Description :

  Proteasome-IN-7 (Compound 6f) is an epoxyketone macrocyclic peptidyl proteasome inhibitor (IC50 value of 37.92 nM for 20S proteasome ChT-L subunit) . Proteasome-IN-7 displays robust antiproliferative effects against multiple myeloma, acute lymphoblastic leukemia and non-small cell lung cancer[1].

• UNSPSC :

  12352211

• Target :

  Proteasome

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  COC(/C=C(C1=C2C=CC=CC2=C3SC[C@H](NC([C@@H](NC([C@H](CCCCN31)NC(C4=CC=CN=C4)=O)=O)CCC5=CC=CC=C5)=O)C(N[C@H](C([C@]6(CO6)C)=O)CC(C)C)=O)\C(OC)=O)=O

• Molecular Formula :

  C48H56N6O10S

• Molecular Weight :

  909.06

• References & Citations :

  [1]Zeng G, et al. Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides. Bioorg Chem. 2025 Mar;156:108180.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported