Verapamil (hydrochloride)

Verapamil (hydrochloride)

• CAS Number: 152-11-4
• UNSPSC Description: Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].
• Target Antigen: Calcium Channel; Cytochrome P450; P-glycoprotein
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Verapamil-hydrochloride.html
• Purity: 99.98
• Solubility: DMSO : ≥ 31 mg/mL|H2O : 50 mg/mL (ultrasonic)
• Smiles: [H]Cl.COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC
• Molecular Weight: 491.06
• References & Citations: [1]Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746.|[2]Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.|[3]Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.|[4]Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81.|[5]Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.Biochem Biophys Res Commun. 2020 Jan 15;521(3):596-602.|Cancer Cell Int. 2021 Feb 16;21(1):108.|Cancer Cell. 2017 Apr 10;31(4):501-515.e8. |Cancer Res Commun. 2024 Apr 9;4(4):1024-1040.|Cancer Sci. 2018 Apr;109(4):1135-1146. |Cancers (Basel). 2021 Aug 6;13(16):3978.|Cell Calcium. 2020 May;87:102171.|Cell Stem Cell. 2023 Apr 6;30(4):378-395.e8.|Comp Biochem Physiol C Toxicol Pharmacol. 2024 Jul 20:109980.|Faculty of Pharmacy in Hradec Králové. Department of Pharmacology and Toxicology. Charles University 2019 Apr.|Food Funct. 2021 Aug 10.|Inflammopharmacology. 2023 Mar 28.|J Pharm Anal. 2020 Apr;10(2):178-186.|Mol Cell Endocrinol. 2019 Aug 20;494:110490. |Pharm Biol. 2019 Dec;57(1):477-484.|Phytomedicine. 2019 Mar 15;56:175-182. |PLoS Biol. 2024 Mar 25;22(3):e3002565.|Preprints. 2024 Jun 12.|SSRN. 2024 Jun 4.|Toxicol Appl Pharmacol. 2019 Apr 1;368:18-25.|Toxicology Research and Application. September 25, 2018.|Toxicology Research and Application. 2018, 2:239784731880115. |Université de Lausanne. 2024 Feb 7.|Xenobiotica. 2019 Dec;49(12):1485-1493. |Adv Mater. 2023 Sep 27:e2211980.|Antibiotics (Basel). 2022 Jul 26;11(8):1005.|Bioact Mater. 2021 Apr 21;6(11):4073-4082.|Biochem Biophys Res Commun. 2023 Nov 24, 149314.|Biochem Biophys Res Commun. 2024 Jan 8:691:149314.|Biomed Chromatogr. 2024 Aug 17:e5984.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Pharmacother. 2024 Oct 13:180:117568.|Biomed Pharmacother. 2024 Oct 28:180:117603.|Biomed Res Int. 2021 May 15.|Br J Pharmacol. 2021 Jul 3.|Braz J Med Biol Res. 2024 Jul 1:57:e13357.|Cell Commun Signal. 2024 Jun 13;22(1):325.|Eur J Pharmacol. 2021 Oct 7;174552.|Eur J Pharmacol. 2022 Oct 25;175343.|Eur J Pharmacol. 2024 Feb 21:176431.|FEBS J. 2024 May 7.|Free Radic Biol Med. 2024 Jun 19:S0891-5849(24)00531-8.|Int J Mol Sci. 2024 Oct 22;25(21):11346.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|J Orthop Surg Res. 2024 Feb 19;19(1):147.|Microbiol Spectr. 2023 Dec 4:e0251023.|Nat Commun. 2024 Jun 19.|Neurochem Res. 2022 Dec 8.|Pak J Pharm Sci. 2022 Mar;35(2):571-578.|Pak J Pharm Sci. 2022 Mar;35(2):587-594.|Pestic Biochem Physiol. August 2022, 105170.|Pharmacol Res Perspect. 2022 Feb;10(1):e00928.|Research (Wash D C). 2024 Feb 21.|Research Square Preprint. 2020 Dec.|Research Square Preprint. 2020 Oct.|Research Square Print. 2022.|SSRN. 8 Nov 2022
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched