(R)-Verapamil-d7 (hydrochloride)

(R)-Verapamil-d7 (hydrochloride)

• UNSPSC Description: (R)-Verapamil-d7 (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].
• Target Antigen: Apoptosis; Isotope-Labeled Compounds; P-glycoprotein
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Membrane Transporter/Ion Channel;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: Cl[H].COC1=C(OC)C=CC(CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C1
• Molecular Weight: 498.11
• References & Citations: [1]Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92.|[2]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported