(S)-Verapamil (hydrochloride)

• UNSPSC Description:

  (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

• Target Antigen:

  Apoptosis; Calcium Channel; Leukotriene Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-verapamil-hydrochloride.html

• Smiles:

  COC1=C(OC)C=CC(CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

• Molecular Weight:

  491.06

• References & Citations:

  [1]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.|[2]Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  36622-28-3