(R)-Verapamil (hydrochloride)

• UNSPSC Description:

  (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

• Target Antigen:

  Apoptosis; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/r-verapamil-hydrochloride.html

• Smiles:

  COC1=C(OC)C=CC(CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

• Molecular Weight:

  491.06

• References & Citations:

  [1]Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92.|[2]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  38176-02-2