HL-2

• Description :

  HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis[1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hl-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=NC=C(C=C1NS(=O)(C2=C(C=C(C=C2)F)F)=O)C3=CN4C(C5=NN=C(O5)C6=C(C=CC=C6)C(O)=O)=CN=C4C=C3

• Molecular Formula :

  C28H18F2N6O6S

• Molecular Weight :

  604.54

• References & Citations :

  [1]Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022;61:116707.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2766352-49-0]