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FBXL2 Rabbit Polyclonal Antibody

CAT: 0992-R1706-15Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1706-15Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G (0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
CAS Number
9007-83-4
Product Name Alternative
DKFZP564P0622 antibody F box and leucine rich repeat protein 2 antibody F box protein containing leucine rich repeats antibody F box protein FBL2/FBL3 antibody F box/LRR repeat protein 2 antibody F-box and leucine-rich repeat protein 2 antibody F-box protein FBL2/FBL3 antibody F-box/LRR-repeat protein 2 antibody FBL 2 antibody FBL 3 antibody FBL2 antibody FBL3 antibody FBXL 2 antibody FBXL2 antibody FBXL2_HUMAN antibody
Abbreviation
FBXL2, FBL2, FBL3
Swiss Prot
Q9UKC9 Human, Q8BH16 Mouse, F1M768 Rat
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide corresponding to Human FBXL2 aa 51-100 / 423.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SiHa cell lysate, Mouse skeletal muscle tissue lysate, Rat skeletal muscle tissue lysate, A431, HUVEC, SiHa, human kidney tissue, mouse kidney tissue, rat kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:10,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:2,000 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 47 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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