FBXL2 Rabbit Polyclonal Antibody
CAT:
992-R1706-15
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FBXL2 Rabbit Polyclonal Antibody
- Description: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G (0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
- Product Name Alternative: DKFZP564P0622 antibody F box and leucine rich repeat protein 2 antibody F box protein containing leucine rich repeats antibody F box protein FBL2/FBL3 antibody F box/LRR repeat protein 2 antibody F-box and leucine-rich repeat protein 2 antibody F-box protein FBL2/FBL3 antibody F-box/LRR-repeat protein 2 antibody FBL 2 antibody FBL 3 antibody FBL2 antibody FBL3 antibody FBXL 2 antibody FBXL2 antibody FBXL2_HUMAN antibody
- Abbreviation: FBXL2, FBL2, FBL3
- CAS Number: 9007-83-4
- Swiss Prot: Q9UKC9 Human, Q8BH16 Mouse, F1M768 Rat
- Cellular Locus: Membrane.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide corresponding to Human FBXL2 aa 51-100 / 423.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: SiHa cell lysate, Mouse skeletal muscle tissue lysate, Rat skeletal muscle tissue lysate, A431, HUVEC, SiHa, human kidney tissue, mouse kidney tissue, rat kidney tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:1,000-1:10,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:2,000 ;FC: 1:1,000
- Purity: Protein A affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 47 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No