FBXL2 Rabbit Polyclonal Antibody

• Description:

  Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G (0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.

• Product Name Alternative:

  DKFZP564P0622 antibody F box and leucine rich repeat protein 2 antibody F box protein containing leucine rich repeats antibody F box protein FBL2/FBL3 antibody F box/LRR repeat protein 2 antibody F-box and leucine-rich repeat protein 2 antibody F-box protein FBL2/FBL3 antibody F-box/LRR-repeat protein 2 antibody FBL 2 antibody FBL 3 antibody FBL2 antibody FBL3 antibody FBXL 2 antibody FBXL2 antibody FBXL2_HUMAN antibody

• Abbreviation:

  FBXL2, FBL2, FBL3

• Swiss Prot:

  Q9UKC9 Human, Q8BH16 Mouse, F1M768 Rat

• Cellular Locus:

  Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide corresponding to Human FBXL2 aa 51-100 / 423.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, FC

• Positive Control:

  SiHa cell lysate, Mouse skeletal muscle tissue lysate, Rat skeletal muscle tissue lysate, A431, HUVEC, SiHa, human kidney tissue, mouse kidney tissue, rat kidney tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000-1:10,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:2,000 ;FC: 1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 47 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4