IREB2 Rabbit Polyclonal Antibody

CAT: 0992-R1706-12Size: 100 µLDry Ice: NoHazardous: No
CAT#:0992-R1706-12Size:100 µL
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Description
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
CAS Number
9007-83-4
Product Name Alternative
ACO3 antibody FLJ23381 antibody IRE BP2 antibody IRE-BP 2 antibody IREB 2 antibody IREB2 antibody IREB2_HUMAN antibody Iron regulatory protein 2 antibody iron responsive element binding protein 2 antibody Iron-responsive element-binding protein 2 antibody IRP 2 antibody IRP2 antibody IRP2AD antibody OTTHUMP00000185022 antibody
Abbreviation
IRE-BP 2, IRP2, IREB2
Swiss Prot
P48200 Human, Q811J3 Mouse, Q62751 Rat
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human IREB2 aa 17-301 / 963.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
K562, mouse kidney tissue lysate, rat skin tissue lysate, 293T, A549, HepG2, human kidney tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 105/38 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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