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IREB2 Polyclonal Antibody

CAT: 0866-RD83774A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD83774A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD) . Alternative splicing results in multiple transcript variants encoding different isoforms.
Description
This is a IREB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
IREB2, ACO3, IRP2, IRP2AD
Gene ID
3658
Swiss Prot
P48200
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human IREB2 (NP_004127.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IF 1:20-1:50
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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