HLA Class 1 ABC Rabbit Polyclonal Antibody

HLA Class 1 ABC Rabbit Polyclonal Antibody

• Description: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9.
• Product Name Alternative: HLA A antibody HLA B antibody HLA C antibody HLA class 1 A antibody HLA class 1 B antibody HLA class 1 C antibody Major histocompatibility complex, class I, A + B + C antibody MHC class I HLA A antibody MHC class I HLA B antibody MHC class I HLA C antibody MHC HLA ABC antibody
• Abbreviation: HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC
• CAS Number: 9007-83-4
• Swiss Prot: P30443 Human, P01889 Human, P30499 Human
• Cellular Locus: Cell membrane, Endoplasmic reticulum membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human HLA Class 1 ABC aa 125-325 / 362.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Hela cell lysate, human colon cancer tissue, human prostate tissue, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:200-1:500 ;FC: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 41 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No