Products for Research Use Only
RegisterLogin

HLA Class 1 ABC Rabbit Polyclonal Antibody

CAT: 0992-R1601-11Size: 100 µLDry Ice: NoHazardous: No
Product image 1Product image 2Product image 3
1 / 3
CAT#:0992-R1601-11Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9.
CAS Number
9007-83-4
Product Name Alternative
HLA A antibody HLA B antibody HLA C antibody HLA class 1 A antibody HLA class 1 B antibody HLA class 1 C antibody Major histocompatibility complex, class I, A + B + C antibody MHC class I HLA A antibody MHC class I HLA B antibody MHC class I HLA C antibody MHC HLA ABC antibody
Abbreviation
HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC
Swiss Prot
P30443 Human, P01889 Human, P30499 Human
Cellular Locus
Cell membrane, Endoplasmic reticulum membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human HLA Class 1 ABC aa 125-325 / 362.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Hela cell lysate, human colon cancer tissue, human prostate tissue, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:200-1:500 ;FC: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 41 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

Related Products

CatalogName
EM1801-09HLA Class 1 ABC Mouse Monoclonal Antibody [11C3]
EM1801-10HLA Class 1 ABC Mouse Monoclonal Antibody [11C2]
HA723415HLA-ABC (MHC I) Recombinant Rabbit monoclonal Antibody
HA751435HLA-ABC (MHC I) Recombinant Rabbit monoclonal Antibody
HA601424HLA Class I Recombinant Mouse monoclonal Antibody
HA610264HLA Class I Recombinant Mouse monoclonal Antibody
HA721927HLA Class II DRB1 Recombinant Rabbit Monoclonal Antibody [JE60-43]
R1510-34HLA-DR Rabbit Polyclonal Antibody
HA500299HLA E Rabbit Polyclonal Antibody
R1510-35HLA-DR Rabbit Polyclonal Antibody

Alternative Products

CatalogName
NBP2-75928Rabbit Polyclonal HLA Class I Antibody
E10G22907MHC Class I Rabbit Polyclonal Antibody
ES8483-01HLA Class I Rabbit Polyclonal Antibody
GTR17744265-01MHC Class II Rabbit Polyclonal Antibody
GTR17846522MHC class I Rabbit Polyclonal Antibody (Cy7)
GTR17840487MHC Class II Rabbit Polyclonal Antibody (Cy7)
GTR17840464MHC Class II Rabbit Polyclonal Antibody (RBITC)
GTR18314702MHC class I Rabbit Polyclonal Antibody (BF594)
GTR18425019MHC Class II Rabbit Polyclonal Antibody (BF555)
GTR18425018MHC Class II Rabbit Polyclonal Antibody (BF594)

Popular Products