HLA Class 1 ABC Mouse Monoclonal Antibody [11C3]

HLA Class 1 ABC Mouse Monoclonal Antibody [11C3]

• Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
• Product Name Alternative: Antigen presenting molecule antibody HLA class I histocompatibility antigen, A 1 alpha chain antibody HLAA antibody Leukocyte antigen class I A antibody Major histocompatibility complex, class I, A antibody MHC class I antigen HLA A heavy chain antibody AS antibody HLA B protein antibody HLA class I histocompatibility antigen, B alpha chain antibody HLA-B antibody HLA-B histocompatibility type antibody HLAB antibody leukocyte antigen class I-B antibody lymphocyte antigen antibody major histocompatibility complex, class I, B antibody MHC class I antigen GN00104 antibody MHC class I antigen HLA-B heavy chain antibody MHC class I antigen SHCHA antibody MHC Class I HLA heavy chain antibody MHC HLA-B cell surface glycoprotein antibody MHC HLA-B transmembrane glycoprotein antibody SPDA1 antibody 1C07_HUMAN antibody Cw-7 alpha chain antibody D6S204 antibody HLA class I histocompatibility antigen antibody HLA class I histocompatibility antigen, C alpha chain antibody HLA class I histocompatibility antigen, Cw-1 alpha chain antibody HLA JY3 antibody HLA-C antibody HLA-C histocompatibility type antibody HLA-Cw antibody HLA-JY3 antibody HLAC antibody HLC C antibody HLC-C antibody human leukocyte antigen-C alpha chain antibody major histocompatibility antigen HLA-C antibody major histocompatibility complex, class I, C antibody MHC class I antigen antibody MHC class I antigen Cw 1 antibody MHC class I antigen Cw*7 antibody MHC class I antigen heavy chain HLA-C antibody PSORS1 antibody
• Abbreviation: HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC
• CAS Number: 9007-83-4
• Swiss Prot: P04439 Human, P01889 Human, P10321 Human
• Cellular Locus: Cell Membrane, Endoplasmic reticulum membrane.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human HLA Class 1 ABC aa 1-362 / 362.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: CAL-62 cell lysate, HeLa cell lysate, HepG2 cell lysate, human liver tissue, 293T.
• Concentration: 2 mg/mL
• Dilution: WB:1:500-1:2000 ;IF-Cell:1:50-1:200 ;IHC-P: 1:5,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 40 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No