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GPC1 Rabbit Polyclonal Antibody

CAT: 0992-R1512-15Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1512-15Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glypican-1 (GPC1), a member of the glycosylphosphatidilinositol anchored cell surface heparan sulfate proteoglycans, is involved with cell adhesion and migration, lipoprotein metabolism, modulation of growth factor activites and anticoagulation. Glypican-1 binds to and modulates the activity of several fibroblast growth factors (FGFs) including FGF-1, FGF-2 and FGF-7. Glypican-1 acts as an extracellular chaperone for VEGF165 to help restore receptor binding ability after oxidation. The heparan sulfate chains of glypican-1 mediate specific binding of glypican-1 to VEGF165. When present on the surface of marrow stromal cells, glypican-1 may aid in the maintenance and development of hematopoietic stem and progenitor cells. Human pancreatic cancer cells express a large amount of glypican-1 when compared to glypican-1 levels in normal pancreatic cells. Glypican-1 may play an important role in the response of pancreatic cancer cells to mitogenic stimuli, such as FGF-2. The gene encoding human glypican-1 maps to chromosome 2q37.3.
CAS Number
9007-83-4
Product Name Alternative
FLJ38078 antibody glypican antibody Glypican proteoglycan 1 antibody glypican1 antibody GPC 1 antibody Gpc1 antibody GPC1_HUMAN antibody Secreted glypican-1 antibody
Abbreviation
GPC1
Swiss Prot
P35052 Human
Cellular Locus
Cell membrane, Endosome, Membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding toHuman GPC1 aa 1-50 / 558.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Hela cell lysate, SK-Br-3 cell lysate, Hela, MCF-7, PANC-1, human breast tissue, human breast cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 61 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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