SHP-1 (PTPN6) Rabbit Polyclonal Antibody

SHP-1 (PTPN6) Rabbit Polyclonal Antibody

• Description: Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway). Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. SHP-1 gene has two promoters: P-1, active in epithelial cells, and P-2, active in hemopoietic cells. In addition the expression of SHP-1 is low in epithelial cells and high in hemopoietic cells. SHP-1 level in epithelial cells increases and in hematopoietic cells decreases in cancer.
• Product Name Alternative: 70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody
• Abbreviation: PTP-1C
• CAS Number: 9007-83-4
• Swiss Prot: P29350 Human, P29351 Mouse, P81718 Rat
• Cellular Locus: Cytoplasm. Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within C-terminal Human SHP-1 aa 550-595 595.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Mouse spleen tissue lysate, A549, Hela, Jurkat, rat spinal cord tissue, human tonsil tissue, human spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 68 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No