Active+Pro Caspase-9 Rabbit Polyclonal Antibody
CAT:
992-R1308-12
Size:
100 µL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Active+Pro Caspase-9 Rabbit Polyclonal Antibody
- Description: Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.
- Product Name Alternative: Caspase9 APAF-3 antibody APAF3 antibody Apoptosis related cysteine peptidase antibody Apoptotic protease Mch-6 antibody Apoptotic protease-activating factor 3 antibody CASP-9 antibody CASP9 antibody CASP9_HUMAN antibody Caspase 9 apoptosis related cysteine peptidase antibody Caspase 9 Dominant Negative antibody Caspase 9c antibody Caspase-9 antibody Caspase-9 subunit p10 antibody ICE LAP6 antibody ICE like apoptotic protease 6 antibody ICE-LAP6 antibody ICE-like apoptotic protease 6 antibody MCH6 antibody PPP1R56 antibody protein phosphatase 1, regulatory subunit 56 antibody RNCASP9 antibody
- Abbreviation: CASP-9,APAF-3,ICE-LAP6
- CAS Number: 9007-83-4
- Swiss Prot: P55211 Human
- Cellular Locus: Cytoplasm.
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Synthetic peptide within human Caspase-9 aa 299-313/416.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P
- Positive Control: HeLa cell lysate, HeLa treated with 1μM staurosporine for 4 hours cell lysate, HeLa treated with 3μM staurosporine for 4 hours cell lysate, human lung carcinoma tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:1,000- 1:2,000 ;IHC-P: 1:200
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 46 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No