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APAF1 Rabbit Polyclonal Antibody

CAT: 0992-R1312-20Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1312-20Size:100 µL
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Description
Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.
CAS Number
9007-83-4
Product Name Alternative
APAF 1 antibody Apaf-1 antibody APAF_HUMAN antibody Apaf1 antibody Apoptotic peptidase activating factor 1 antibody Apoptotic protease activating factor 1 antibody Apoptotic protease activating factor antibody Apoptotic protease-activating factor 1 antibody CED 4 antibody CED4 antibody KIAA0413 antibody
Abbreviation
APAF-1
Swiss Prot
O14727 Human, O88879 Mouse
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within Human APAF1 aa 1,191-1240 / 1,248.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
HepG2, THP-1
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 142 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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