E-cadherin Mouse Monoclonal Antibody [3-F9]

• Description:

  E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer.

• Product Name Alternative:

  Arc 1 antibody CADH1_HUMAN antibody Cadherin 1 antibody cadherin 1 type 1 E-cadherin antibody Cadherin1 antibody CAM 120/80 antibody CD 324 antibody CD324 antibody CD324 antigen antibody cdh1 antibody CDHE antibody E-Cad/CTF3 antibody E-cadherin antibody ECAD antibody Epithelial cadherin antibody epithelial calcium dependant adhesion protein antibody LCAM antibody Liver cell adhesion molecule antibody UVO antibody Uvomorulin antibody

• Abbreviation:

  E-cadherin

• Swiss Prot:

  P12830 Human, P09803 Mouse

• Cellular Locus:

  Cell membrane

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein within mouse E-Cadherin aa 350-550.

• Isotype:

  IgG2b

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  IHC-P

• Positive Control:

  Human liver tissue, mouse liver tissue.

• Concentration:

  2 mg/mL

• Dilution:

  IHC-P: 1:200

• Purity:

  Protein G affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  ~130kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4