Claudin 1 Recombinant Rabbit Monoclonal Antibody [PS01-43]

Claudin 1 Recombinant Rabbit Monoclonal Antibody [PS01-43]

• Description: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
• Product Name Alternative: Claudin-1 antibody Claudin1 antibody CLD 1 antibody CLD1 antibody CLD1_HUMAN antibody CLDN 1 antibody Cldn1 antibody ILVASC antibody SEMP 1 antibody SEMP1 antibody Senescence associated epithelial membrane protein 1 antibody Senescence associated epithelial membrane protein antibody Senescence-associated epithelial membrane protein antibody
• Abbreviation: Claudin-1 Senescence-associated epithelial membrane protein CLDN1 CLD1 SEMP1 UNQ481 PRO944
• CAS Number: 9000-83-3
• Swiss Prot: O95832 Human
• Cellular Locus: Cell junction, Cell membrane, Membrane, Tight junction
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant full length protein within human Claudin 1.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Tissue, IF-Cell
• Positive Control: A431 cell lysate, HepG2 cell lysate, human tonsil tissue, human skin tissue, A431, HepG2.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000 ;IF-Tissue: 1:200 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 23 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes