Claudin 18.2 Rabbit Polyclonal Antibody

Claudin 18.2 Rabbit Polyclonal Antibody

• Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Product Name Alternative: Claudin 18 antibody Claudin-18 antibody CLD18_HUMAN antibody CLDN18 antibody SFTA5 antibody SFTPJ antibody
• Abbreviation: CLDN18
• CAS Number: 9007-83-4
• Swiss Prot: P56856 Human, P56856-2 Human, P56857 Mouse,
• Cellular Locus: Cell membrane, tight junction.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide corresponding to N terminal of Human CLDN18.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Rat heart tissue lysates, MG-63, human stomach tissue, mouse stomach tissue, rat stomach tissue, F9.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:2,000 ;IF-Cell:1:50-1:200 ;IHC-P:1:8,000 ;FC:1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 28 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No