Claudin 7 Recombinant Mouse Monoclonal Antibody [6-G3-R]

Claudin 7 Recombinant Mouse Monoclonal Antibody [6-G3-R]

• Description: Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells. It is expressed in kidney, lung and prostate. Claudin-7 is down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
• Product Name Alternative: CEPTR L2 antibody CEPTRL 2 antibody CEPTRL2 antibody Claudin 1 antibody Claudin 9 antibody Claudin-7 antibody Claudin1 antibody Claudin7 antibody Claudin9 antibody CLD7_HUMAN antibody CLDN 7 antibody CLDN-7 antibody CLDN7 antibody Clostridium perfringens enterotoxin receptor like 2 antibody CPETR L2 antibody CPETRL 2 antibody CPETRL2 antibody Hs.84359 antibody
• Abbreviation: CLDN-7
• CAS Number: 9000-83-3
• Swiss Prot: O95471 Human, Q9Z261 Mouse, Q9Z1L1 Rat
• Cellular Locus: Cell membrane, Basolateral cell membrane, Cell junction, tight junction.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Claudin 7 aa 162-211 / 211.
• Isotype: IgG1
• Clone: 6-G3-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, IF-Tissue, IP
• Positive Control: SW480 cell lysate, MCF7 cell lysate, LNCaP cell lysate, Caco-2 cell lysate, A431 cell lysate, mouse colon tissue lysate, rat colon tissue lysate, PC-12, human kidney tissue, human colon tissue, mouse colon tissue, rat colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:5,000 ;IF-Tissue: 1:200-1:1,000 ;IP: 1-2μg/sample
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 22 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes