LMO2 Recombinant Rabbit Monoclonal Antibody [PD00-25]

LMO2 Recombinant Rabbit Monoclonal Antibody [PD00-25]

• Description: The LIM-domain-only (LMO) family of proteins function as linkers in the co-regulation of nuclear transcription by mediating protein-protein interactions. The four members of the LMO family collectively have significant roles in cell fate determination, cell growth and differentiation, and organ development. LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms. LMO2 has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymphangiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma. The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.
• Product Name Alternative: Cysteine rich protein TTG 2 antibody Cysteine rich protein TTG2 antibody Cysteine-rich protein TTG-2 antibody LIM domain only 2 (rhombotin like 1) antibody LIM domain only 2 antibody LIM domain only protein 2 antibody LMO 2 antibody LMO-2 antibody lmo2 antibody RBTN 2 antibody RBTN L1 antibody RBTN2 antibody RBTN2_HUMAN antibody RBTNL 1 antibody RBTNL1 antibody RHOM 2 antibody RHOM2 antibody Rhombotin 2 antibody Rhombotin like 1 antibody Rhombotin-2 antibody Rhombotin2 antibody T cell translocation gene 2 antibody T cell translocation protein 2 antibody T-cell translocation protein 2 antibody TTG 2 antibody TTG2 antibody
• Abbreviation: LMO2
• CAS Number: 9000-83-3
• Swiss Prot: P25791 Human, P25801 Mouse
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein full length human LMO2.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: K562 cell lysates, mouse brain tissue, human tonsil tissue, human lymph nodes tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000-1:2000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 18 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes