Fbxw7 Recombinant Rabbit Monoclonal Antibody [PD00-51]

Fbxw7 Recombinant Rabbit Monoclonal Antibody [PD00-51]

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
• Product Name Alternative: AGO antibody Archipelago antibody Archipelago homolog antibody Archipelago, Drosophila, homolog of antibody CDC4 antibody CDC4, S.cerevisiae, homolog of antibody DKFZp686F23254 antibody F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody F box and WD 40 domain protein 7 antibody F box and WD repeat domain containing 7 antibody F box protein FBW7 antibody F box protein FBX30 antibody F box protein SEL 10 antibody F box protein SEL10 antibody F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody F-box and WD-40 domain-containing protein 7 antibody F-box protein FBX30 antibody F-box/WD repeat-containing protein 7 antibody FBW6 antibody FBW7 antibody FBX30 antibody FBXO30 antibody FBXW6 antibody FBXW7 antibody FBXW7_HUMAN antibody FLJ16457 antibody hAgo antibody hCdc4 antibody Homolog of C elegans sel 10 antibody Homolog of C.elegans sel10 antibody SEL 10 antibody SEL-10 antibody SEL10 antibody
• Abbreviation: FBXW7
• CAS Number: 9000-83-3
• Swiss Prot: Q969H0 Human
• Cellular Locus: Chromosome, Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IHC-P
• Positive Control: Human bladder carcinoma tissue, human colon carcinoma tissue, human stomach carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: IHC-P: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size:
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes