iFluor™ 488 Conjugated Cytokeratin 16 Recombinant Rabbit Monoclonal Antibody [SC52-09]

iFluor™ 488 Conjugated Cytokeratin 16 Recombinant Rabbit Monoclonal Antibody [SC52-09]

• Description: Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
• Product Name Alternative: CK 16 antibody CK-16 antibody CK16 antibody Cytokeratin-16 antibody Cytokeratin16 antibody FNEPPK antibody Focal non epidermolytic palmoplantar keratoderma antibody K 16 antibody K16 antibody K1C16_HUMAN antibody K1CP antibody Keratin 1 type I antibody Keratin 16 antibody Keratin antibody Keratin type I cytoskeletal 16 antibody Keratin-16 antibody Keratin16 antibody KRT 16 antibody Krt16 antibody KRT16A antibody NEPPK antibody PC1 antibody type I cytoskeletal 16 antibody
• Abbreviation: CK-16, K16, KRT16A
• CAS Number: 9000-83-3
• Swiss Prot: P08779 Human
• Cellular Locus: Cytoskeleton, Nucleus.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within human Cytokeratin 16 aa 27-75.
• Isotype: IgG
• Conjugation: iFluor™ 488
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Tissue, IF-Cell, FC
• Positive Control: Human esophagus tissue, human skin tissue, HepG2, A431.
• Concentration: 1 mg/mL
• Dilution: IF-Tissue: 1:50-1:200 ;IF-Cell: 1:50-1:100 ;FC: 1ug/mL
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
• Molecular Weight: Predicted band size: 51 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes