iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]

iFluor™ 488 Conjugated Cytokeratin 8 Recombinant Rabbit Monoclonal Antibody [SU0338]

• Description: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.
• Product Name Alternative: CARD2 antibody Cell proliferation inducing gene 46 protein antibody Cell proliferation inducing protein 46 antibody CK 8 antibody CK-8 antibody CK8 antibody CYK8 antibody Cytokeratin 8 antibody Cytokeratin-8 antibody K2C8 antibody K2C8_HUMAN antibody K8 antibody Keratin 8 antibody Keratin antibody keratin type II cytoskeletal 8 antibody Keratin-8 antibody KRT8 antibody type II cytoskeletal 8 antibody Type-II keratin Kb8 antibody
• Abbreviation: CK-8, K8, KRT8, CYK8
• CAS Number: 9000-83-3
• Swiss Prot: P05787 Human
• Cellular Locus: Nucleoplasm, Nucleus matrix, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.
• Isotype: IgG
• Conjugation: iFluor™ 488
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Tissue, IF-Cell
• Positive Control: Human liver tissue, SK-Br-3, human breast tissue.
• Concentration: 1 mg/mL
• Dilution: IF-Tissue: 1:200;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.
• Molecular Weight: Predicted band size: 54 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes