BCL6 Recombinant Mouse Monoclonal Antibody [A6C7-R]

BCL6 Recombinant Mouse Monoclonal Antibody [A6C7-R]

• Description: The Bcl-6 protein (B-cell CLL/lymphoma 6, zinc finger protein 51) is a nuclear zinc finger transcription factor with an N-terminal POZ domain. Bcl-6 represses p53 transcription by binding 2 specific DNA sites within the p53 promoter region and accordingly, p53 expression is absent in germinal centre B-cells where Bcl-6 is highly expressed. Most notably, constitutive expression of Bcl-6 protects B-cell lines from apoptosis induced by DNA damage. Bcl-6 is mainly used in the classification of B-cell lymphomas. In malignant lymphomas, Bcl-6 protein is most commonly detected in germinal centre neoplasms including follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (40%), lymphocyte predominant Hodgkin lymphoma, and even in peripheral T-cell lymphoma with follicular localization (“follicular T cell lymphoma”). It is also found in CD30+ anaplastic large cell lymphoma. Bcl-6 expression is virtually absent in acute lymphatic leukaemia and mantle cell lymphoma. Normal tonsil is recommended as positive and negative tissue control. Virtually all the germinal centre B-cells must show a moderate to strong nuclear staining reaction, while an at least weak to moderate nuclear staining reaction must be seen in the majority of squamous epithelial cells. In the mantle zones and interfollicular areas only dispersed cells should display a positive nuclear staining reaction.
• Product Name Alternative: B cell CLL/lymphoma 6 antibody B cell lymphoma 6 protein antibody B-cell lymphoma 5 protein antibody B-cell lymphoma 6 protein antibody BCL 5 antibody Bcl 6 antibody BCL-5 antibody BCL-6 antibody BCL5 antibody BCL6 antibody BCL6_HUMAN antibody BCL6A antibody cys his2 zinc finger transcription factor antibody cys-his2 zinc finger transcription factor antibody LAZ 3 antibody LAZ 3 protein antibody LAZ3 antibody Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody Lymphoma associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB 27 antibody ZBTB27 antibody Zinc finger and BTB domain containing protein 27 antibody Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc Finger Protein 51 (ZNF51) antibody Zinc finger protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF 51 antibody ZNF51 antibody
• Abbreviation: BCL6
• CAS Number: 9000-83-3
• Swiss Prot: P41182 Human
• Cellular Locus: Nucleus.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human BCL-6 aa 301-500 / 706.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: IHC-P, IF-Cell, mIHC
• Positive Control: Human B lymphocytoma tissue, human lymph nodes tissue, Raji, Human tonsil.
• Concentration: 1.026 mg/mL
• Dilution: IHC-P: 1:1,000 ;IF-Cell: 1:200 ;mIHC: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 79 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes