TRIM72 Recombinant Mouse Monoclonal Antibody [A1D4-R]

TRIM72 Recombinant Mouse Monoclonal Antibody [A1D4-R]

• Description: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
• Product Name Alternative: LOC493829 antibody Mg53 antibody Mitsugumin-53 antibody TRI72_HUMAN antibody trim72 antibody Tripartite motif containing 72 antibody Tripartite motif containing protein 72 antibody Tripartite motif-containing protein 72 antibody
• Abbreviation: TRIM72
• CAS Number: 9000-83-3
• Swiss Prot: Q6ZMU5 Human, Q1XH17 Mouse, A0JPQ4 Rat
• Cellular Locus: Sarcolemma, cytoplasmic vesicle membrane.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein with Human TRIM72 aa 50-150 / 477.
• Isotype: IgG1
• Clone: A1D4-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB
• Positive Control: HCT 116 cell lysate, mouse skeletal muscle tissue lysate, mouse heart tissue lysate, rat heart tissue lysate, rat skeletal muscle tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 53 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes