Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]

Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]

• Description: Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, downregulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. Downregulates as well the function of host natural killer cells. Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells. However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation.
• Product Name Alternative: GP 1,2 antibody GP antibody GP1 antibody GP2 antibody GP2-delta antibody Spike glycoprotein antibody Virion spike glycoprotein antibody
• Abbreviation: GP1,2 GP1 GP2 Shed GP GP1,2-delta GP
• CAS Number: 9007-83-4
• Swiss Prot: P87666 Zaire Ebola virus
• Cellular Locus: Virion membrane, Host cell membrane, Secreted.
• Host: Mouse
• Species Reactivity: Zaire ebolavirus
• Immunogen: Synthetic peptide within Zaire Ebola virus Envelope glycoprotein aa 400-450.
• Isotype: IgG2b
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: ELISA
• Concentration: 2 mg/mL
• Dilution: ELISA: 1:10.000
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 74 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No