P Glycoprotein Rabbit Polyclonal Antibody

• Description:

  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

• Product Name Alternative:

  ABC20 antibody ABCB1 antibody ATP binding cassette, sub family B (MDR/TAP), member 1 antibody ATP-binding cassette sub-family B member 1 antibody CD243 antibody CLCS antibody Colchicin sensitivity antibody Doxorubicin resistance antibody GP170 antibody MDR1 antibody MDR1_HUMAN antibody Multidrug resistance 1 antibody Multidrug resistance protein 1 antibody P glycoprotein 1 antibody P gp antibody P-glycoprotein 1 antibody PGY1 antibody

• Abbreviation:

  ABCB1

• Swiss Prot:

  P08183 Human, P06795 Mouse, P43245 Rat

• Cellular Locus:

  Cell membrane, Apical cell membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within human P Glycoprotein aa 733-756 / 1,280.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  HepG2 cell lysate, Hela cell lysate, human kidney tissue, human small intestine tissue, human thyroid carcinoma tissue, mouse kidney tissue, rat brain tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500 ;IHC-P: 1:200-1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  141 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4