Fusion glycoprotein F0 Rabbit Polyclonal Antibody

Fusion glycoprotein F0 Rabbit Polyclonal Antibody

• Description: During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
• Product Name Alternative: F antibody Fusion glycoprotein F0 antibody Protein F antibody RSV Fusion (F) Glycoprotein antibody
• Abbreviation: F
• CAS Number: 9007-83-4
• Swiss Prot: W8CLH7 Avian avulavirus 1
• Cellular Locus: Host cell membrane. Virion membrane.
• Host: Rabbit
• Species Reactivity: Avian avulavirus 1
• Immunogen: Synthetic peptide within newcastle disease virus Fusion glycoprotein F0 aa 86-135 / 553.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, ELISA
• Positive Control: Fusion glycoprotein F0 transfected HEK293 cell.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1,000;ELISA: 1:5,000-1:10,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 59 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No